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They are usually prescribed for patients with osteoporosis or other metastatic bone diseases [clarification needed], such as Paget's disease, osteogenesis imperfecta and fibrous dysplasia. [28] [29] The two main types of anti-resorptive drugs are bisphosphonate and denosumab. These drugs help to decrease the risk of bone fracture and bone pain.
Bazedoxifene is used in the prevention of postmenopausal osteoporosis. [5] Osteoporosis represents a major public health concern, especially as the number of postmenopausal women continues to rise. As a result, the need for innovative treatments has become increasingly important.
Osteoporosis is a systemic skeletal disorder characterized by low bone mass, micro-architectural deterioration of bone tissue leading to more porous bone, and consequent increase in fracture risk. It is the most common reason for a broken bone among the elderly . [ 3 ]
Senile osteoporosis has been recently recognized as a geriatric syndrome with a particular pathophysiology. There are different classification of osteoporosis: primary, in which bone loss is a result of aging and secondary, in which bone loss occurs from various clinical and lifestyle factors. [1]
Bisphosphonates are used to treat osteoporosis, osteitis deformans (Paget's disease of the bone), bone metastasis (with or without hypercalcemia), multiple myeloma, and other conditions involving fragile, breakable bone. In osteoporosis and Paget's, the most popular first-line bisphosphonate drugs are alendronate and risedronate.
It is an effective anabolic (promoting bone formation) agent [15] used in the treatment of some forms of osteoporosis. [13] [16] Teriparatide is a recombinant human parathyroid hormone analog (PTH 1-34). [13] It has an identical sequence to the 34 N-terminal amino acids of the 84-amino acid human parathyroid hormone. [13]
Abaloparatide, sold under the brand name Tymlos among others, is a parathyroid hormone-related protein (PTHrP) analog medication used to treat osteoporosis. [2] It is an anabolic (i.e., bone growing) agent. [4] The most common side effects include hypercalciuria (high calcium levels in the urine) and dizziness. [3]
Raloxifene is used for the treatment and prevention of osteoporosis in postmenopausal women. [11] It is used at a dosage of 60 mg/day for both the prevention and treatment of osteoporosis. [12] In the case of either osteoporosis prevention or treatment, supplemental calcium and vitamin D should be added to the diet if daily intake is inadequate ...