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Undertreatment of pain is the absence of pain management therapy for a person in pain when treatment is indicated. Consensus in evidence-based medicine and the recommendations of medical specialty organizations establish guidelines to determine the treatment for pain which health care providers ought to offer. [91]
Where is the pain? Or the maximal site of the pain. O Onset When did the pain start, and was it sudden or gradual? Include also whether it is progressive or regressive. C Character What is the pain like? An ache? Stabbing? R Radiation: Does the pain radiate anywhere? A Associations Any other signs or symptoms associated with the pain? T Time course
It was considered a first-aid treatment rather than a cure and aimed to control inflammation. [2] It was thought that the reduction in pain and swelling that occurred as a result of decreased inflammation helped with healing. [1] The protocol was often used to treat sprains, strains, cuts, bruises, and other similar injuries. [3]
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Central pain syndrome, also known as central neuropathic pain, [1] is a neurological condition consisting of constant moderate to severe pain due to damage to the central nervous system (CNS) which causes a sensitization of the pain system. [2] [3] The extent of pain and the areas affected are related to the cause of the injury. [4]
Complex regional pain syndrome (CRPS Type 1 and Type 2), sometimes referred to by the hyponyms Reflex Sympathetic Dystrophy (RSD) or Reflex Neurovascular Dystrophy (RND), is a rare and severe form of neuroinflammatory and dysautonomic disorder causing chronic pain, neurovascular, and neuropathic symptoms.
Neuropathic pain has profound physiological effects on the brain which can manifest as psychological disorders. Rodent models where the social effects of chronic pain can be isolated from other factors suggest that induction of chronic pain can cause anxio-depressive symptoms and that particular circuits in the brain have a direct connection.
A per-protocol analysis represents a "best-case scenario" to reveal the effect of the drug being studied. However, by restricting the analysis to a selected patient population, it does not show all effects of the new drug. Further, adherence to treatment may be affected by other factors that influence the outcome.