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Summation, which includes both spatial summation and temporal summation, is the process that determines whether or not an action potential will be generated by the combined effects of excitatory and inhibitory signals, both from multiple simultaneous inputs (spatial summation), and from repeated inputs (temporal summation).
DANDI: Distributed Archives for Neurophysiology Data Integration: cellular neurophysiology data including electrophysiology, optophysiology, and behavioral time-series, and images from immunostaining experiments Human and several other species Multiscale Spike trains, LFP, MUA, MRI Healthy Database for Reaching Experiments And Models (DREAM)
Temporal summation means that the effects of impulses received at the same place can add up if the impulses are received in close temporal succession. Thus the neuron may fire when multiple impulses are received, even if each impulse on its own would not be sufficient to cause firing.
Ramanujan summation is a technique invented by the mathematician Srinivasa Ramanujan for assigning a value to divergent infinite series.Although the Ramanujan summation of a divergent series is not a sum in the traditional sense, it has properties that make it mathematically useful in the study of divergent infinite series, for which conventional summation is undefined.
Bernard Katz pioneered the study of these mEPSPs at the neuromuscular junction (often called miniature end-plate potentials [6]) in 1951, revealing the quantal nature of synaptic transmission. Quantal size can then be defined as the synaptic response to the release of neurotransmitter from a single vesicle, while quantal content is the number ...
[1] According to temporal summation one would expect the inhibitory and excitatory currents to be summed linearly to describe the resulting current entering the cell. However, when inhibitory and excitatory currents are on the soma of the cell, the inhibitory current causes the cell resistance to change (making the cell "leakier"), thereby ...
Holonomic brain theory is a branch of neuroscience investigating the idea that consciousness is formed by quantum effects in or between brain cells. Holonomic refers to representations in a Hilbert phase space defined by both spectral and space-time coordinates. [1]
[1] [10] These three processes are often differentiated by their time scales: facilitation usually lasts for tens of milliseconds, while augmentation acts on a time scale on the order of seconds and potentiation has a time course of tens of seconds to minutes. All three effects increase the probability of neurotransmitter release from the ...