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A steady-state plasma level of dofetilide is achieved in 2–3 days. 80% of dofetilide is excreted by the kidneys, so the dose of dofetilide should be adjusted in individuals with chronic kidney disease, based on creatinine clearance. In the kidneys, dofetilide is eliminated via cation exchange (secretion).
Dofetilide blocks only the rapid K channels; this means that at higher heart rates, when there is increased involvement of the slow K channels, dofetilide has less of an action potential-prolonging effect. Sotalol is indicated for the treatment of atrial or ventricular tachyarrhythmias, and AV re-entrant arrhythmias.
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DigitAlb Sh.A is an Albanian media, digital satellite and terrestrial TV platform based in Tirana, Albania. [1] [2] The TV platform began terrestrial broadcasts on 15 July 2004, and satellite broadcasts by the end of that year.
Television in Albania was first introduced in 1960. RTSH dominated the Albanian broadcasting field up to the mid-90s, a period when privately owned radio and TV stations started to occupy the vast empty Albanian frequencies.
Gabapentin is recommended for use in focal seizures and neuropathic pain. [7] [10] Gabapentin is prescribed off-label in the US and the UK, [22] [23] for example, for the treatment of non-neuropathic pain, [22] anxiety disorders, sleep problems and bipolar disorder. [24]
SuperSport is an Albanian group of television sports channels operated by terrestrial television platform DigitAlb.The channels broadcast a range of different sports such as the English Premier League, Spanish La Liga, German Bundesliga and Bundesliga 2, Dutch Eredivisie, French Ligue 1 and Ligue 2, UEFA Europa League, UEFA Euro, UEFA Europa Conference League, Copa América, ATP 500, ATP 1000 ...