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While at UCL Clark wrote the first edition of his textbook Applied Pharmacology [13] in 1923, a book that was to be updated by two of his successors as Head of department, first by H.O. Schild and later by H.P. Rang, and is still extant in the form of the widely used textbook Rang & Dale's Pharmacology. [14]
Antiarrhythmic agents, also known as cardiac dysrhythmia medications, are a class of drugs that are used to suppress abnormally fast rhythms (tachycardias), such as atrial fibrillation, supraventricular tachycardia and ventricular tachycardia.
Martindale aims to cover drugs and related substances reported to be of clinical interest anywhere in the world. It provides health professionals with a useful source of information to identify medicines, such as confirming the drug and brand name of a medication being taken by a patient arriving from abroad.
The therapeutic index (TI; also referred to as therapeutic ratio) is a quantitative measurement of the relative safety of a drug with regard to risk of overdose.It is a comparison of the amount of a therapeutic agent that causes toxicity to the amount that causes the therapeutic effect. [1]
Drug antagonism refers to a medicine stopping the action or effect of another substance, preventing a biological response. [1] [2] The stopping actions are carried out by four major mechanisms, namely chemical, pharmacokinetic, receptor and physiological antagonism. [2]
Agonist vs. antagonist. In pharmacology the term agonist-antagonist or mixed agonist/antagonist is used to refer to a drug which under some conditions behaves as an agonist (a substance that fully activates the receptor that it binds to) while under other conditions, behaves as an antagonist (a substance that binds to a receptor but does not activate and can block the activity of other agonists).
Beta blockers exert their pharmacological effect, decreased heart rate, by binding to and competitively antagonising a type of receptor called beta adrenoceptors. [1]In pharmacology, the term mechanism of action (MOA) refers to the specific biochemical interaction through which a drug substance produces its pharmacological effect. [2]
In pharmacology, potency or biological potency [1] is a measure of a drug's biological activity expressed in terms of the dose required to produce a pharmacological effect of given intensity. [2]
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