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The 1,2,3-isomer is unstable and ring-opens to form the diazo ketone tautomer; [2] however, it does exist within the unusual sydnone motif. [ 1 ] In 2018, a compound called bis(1,2,4-oxadiazole)bis(methylene) dinitrate which might have 1.5 times the power of TNT was developed at the United States Army Research Laboratory (ARL) working with the ...
For example, the azole antifungals such as ketoconazole or itraconazole can be both substrates and inhibitors of the P-glycoprotein, which (among other functions) excretes toxins and drugs into the intestines. [34] Azole antifungals are also both substrates and inhibitors of the cytochrome P450 family CYP3A4, [34] causing increased ...
Fungistatics are anti-fungal agents that inhibit the growth of fungus (without killing the fungus). [1] The term fungistatic may be used as both a noun and an adjective . Fungistatics have applications in agriculture, the food industry, the paint industry, and medicine.
One, and only one, lone pair of electrons from each heteroatom in the ring is part of the aromatic bonding in an azole. Names of azoles maintain the prefix upon reduction (e.g., pyrazoline, pyrazolidine). The numbering of ring atoms in azoles starts with the heteroatom that is not part of a double bond, and then proceeds towards the other ...
The names on the list are the ISO common name for the active ingredient which is formulated into the branded product sold to end-users. [1] The University of Hertfordshire maintains a database of the chemical and biological properties of these materials, [2] including their brand names and the countries and dates where and when they have been ...
The semisynthetic pneumocandin analogs of echinocandins were later found to have the same kind of antifungal activity, but low toxicity. The first of these newer echinocandins to be approved by the U.S. Food and Drug Administration was caspofungin, and later micafungin and anidulafungin were also approved.
Benzimidazole is a base: . C 6 H 4 N(NH)CH + H + → [C 6 H 4 (NH) 2 CH] +. It can also be deprotonated with stronger bases: . C 6 H 4 N(NH)CH + LiH → Li [C 6 H 4 N 2 CH] + H 2. The imine can be alkylated and also serves as a ligand in coordination chemistry.
Plantazolicin (PZN) is a natural antibiotic produced by the gram-positive soil bacterium Bacillus velezensis FZB42 [1] (previously Bacillus amyloliquefaciens FZB42). [2] PZN has specifically been identified as a selective bactericidal agent active against Bacillus anthracis, the causative agent of anthrax.