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Cinnamic acid is an organic compound with the formula C 6 H 5-CH=CH-COOH. It is a white crystalline compound that is slightly soluble in water, and freely soluble in many organic solvents. [ 4 ] Classified as an unsaturated carboxylic acid , it occurs naturally in a number of plants.
A derivative of trifluorotoluene, 3-aminobenzotrifluoride, is the precursor to the herbicide fluometuron. [3] It is synthesized via nitration followed by reduction to meta-H 2 NC 6 H 4 CF 3. This aniline is then converted to the urea. Flumetramide (6-[4-(trifluoromethyl)phenyl]morpholin-3-one), a skeletal muscle relaxant, is also prepared from ...
Trifluoroacetone is produced from trifluoroacetoacetic acid, which is synthesized by condensation of ethyl trifluoroacetate and ethyl acetate: CF 3 CO 2 C 2 H 5 + CH 3 CO 2 C 2 H 5 → CF 3 C(O)CH 2 CO 2 C 2 H 5 + C 2 H 5 OH. Hydrolysis of the keto-ester, followed by decarboxylation affords trifluoroacetone: CF 3 C(O)CH 2 CO 2 C 2 H 5 + H 2 O ...
[4] It can be used in place of oxalyl chloride in the Swern oxidation, allowing temperatures up to −30 °C. [5] With sodium iodide, it reduces sulfoxides to sulfides. [4] Trifluoroacetic anhydride is the recommended desiccant for trifluoroacetic acid. [6]
The trifluoromethyl group is a functional group that has the formula-CF 3. The naming of is group is derived from the methyl group (which has the formula -CH 3), by replacing each hydrogen atom by a fluorine atom. Some common examples are trifluoromethane H– CF 3, 1,1,1-trifluoroethane H 3 C – CF 3, and hexafluoroacetone F 3 C –CO– CF 3.
Trifluoroethanol is produced industrially by hydrogenation or the hydride reduction of derivatives of trifluoroacetic acid, such as the esters or acyl chloride. [1]TFE can also be prepared by hydrogenolysis of compounds of generic formula CF 3 −CHOH−OR (where R is hydrogen or an alkyl group containing from one to eight carbon atoms), in the presence of a palladium containing catalyst ...
The first to investigate trifluoromethyl groups in relationship to biological activity was F. Lehmann in 1927. [5] An early review appeared in 1958. [6] An early synthetic method was developed by Frédéric Swarts in 1892, [7] based on antimony fluoride. In this reaction benzotrichloride was reacted with SbF 3 to form PhCF 2 Cl and PhCF 3.
Trifluoroacetic acid (TFA) is a synthetic organofluorine compound with the chemical formula CF 3 CO 2 H. It is a haloacetic acid, with all three of the acetyl group's hydrogen atoms replaced by fluorine atoms. It is a colorless liquid with a vinegar-like odor.