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In a study involving 400 men aged 50 – 69, MRI screening identified more men with prostate cancer than PSA tests or ultrasound and did not increase the number of men who needed a biopsy. [36] [37] A large-scale trial of MRI screening, TRANSFORM, began in the UK in spring 2024. [38]
In men aged 55–69 who have been counseled on the known harms and potential benefits of prostate cancer screening, the U.S. Preventive Service Task Force May 2018 statement states, "The use of digital rectal examination as a screening modality is not recommended because there is a lack of evidence on the benefits."
The field strength of the magnet is measured in teslas – and while the majority of systems operate at 1.5 T, commercial systems are available between 0.2 and 7 T. 3T MRI systems, also called 3 Tesla MRIs, have stronger magnets than 1.5 systems and are considered better for images of organs and soft tissue. [7]
In fact, a side-by-side comparison of TRUS versus MRI-guided targeted biopsy that was conducted as a prospective, investigator-blinded study demonstrated that MRI-guided biopsy improved detection of significant prostate cancer by 17.7%, and decreased the diagnosis of insignificant or low-risk disease by 89.4%. [12]
PET-MRI systems don't offer a direct way to obtain attenuation maps, unlike stand-alone PET or PET-CT systems. [ 32 ] [ 33 ] Stand alone PET systems' attenuation correction (AC) is based on a transmission scan (mu - map) acquired using a 68 Ge ( Germanium-68 ) rotating rod source, which directly measures photon attenuation at 511 keV.
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The technique has demonstrated higher accuracy than other modalities in assessing seminal vesicle invasion and extra-capsular extension (ECE) of prostate cancer (96% and 81% respectively). Endorectal coil MRI is useful for determining the extent of spread and local invasion of cancers of the prostate, rectum, and anus. [2]
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