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Congenital insensitivity to pain (CIP), also known as congenital analgesia, is one or more extraordinarily rare conditions in which a person cannot feel (and has never felt) physical pain. [1] The conditions described here are separate from the HSAN group of disorders, which have more specific signs and cause.
Some inhabitants near Gällivare, mainly in the village of Tjautjas (also Tjautjasjaure or Čavččas) 20 km outside Gällivare, have a remarkably high incidence of congenital insensitivity to pain, an extremely rare disease which inhibits the sensation of pain, heat and cold. There have been nearly 40 reported cases in the area.
Those affected are unable to feel pain and temperature. [2] [3] The absence of pain experienced by people with CIPA puts them at high risk for accidental self-injury. Corneal ulceration occurs due to lack of protective impulses. [4] Joint and bone problems are common due to repeated injuries, and wounds heal poorly. [5]
1960: Ervin and Sternbach describe 6 members from a 2-generation family with dominantly-inherited congenital insensitivity to pain. [ 4 ] 1974: Comings and Amromin describe 3 members from a 2-generation family which consisted of a mother, her son and her daughter with the symptoms characteristic of Marsili syndrome, there was a possibility that ...
Congenital Insensitivity to Pain (CIP) is a genetic disorder causing channelopathy while Congenital Insensitivity to Pain with Anhydrosis (CIPA) is a genetic disorder of affecting the formation of nerve growth factor, or other genetic disorders.
Vittangi (Swedish pronunciation: [ˈvɪ̌tːaŋɡɪ]; [2] Meänkieli: Vittanki; Northern Sámi: Vazáš) is a locality situated in Kiruna Municipality, Norrbotten County, Sweden with 784 inhabitants in 2010. [1] The village of Vittangi was founded in 1674 by Henrik Mickelsson Kyrö from Pello.
Opposition to anesthesia has since dissipated; however, the prospect of eradicating pain raises similar concerns about interfering with life's natural functions. [ 2 ] People who are naturally incapable of feeling pain or unpleasant sensations due to rare conditions like pain asymbolia or congenital insensitivity to pain have been studied to ...
FD results in variable symptoms, including insensitivity to pain, inability to produce tears, poor growth, and labile blood pressure (episodic hypertension and postural hypotension). People with FD have frequent vomiting crises, pneumonia , problems with speech and movement, difficulty swallowing , and inappropriate perception of heat, pain and ...