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RNA polymerase II (also called RNAP II and Pol II) is an enzyme found in eukaryotic cells. It catalyzes the transcription of DNA to synthesize precursors of mRNA and most snRNA and microRNA . [ 3 ] [ 4 ] In humans, RNAP II consists of seventeen protein molecules (gene products encoded by POLR2A-L, where the proteins synthesized from POLR2C ...
RNA polymerase II (RNAP II and Pol II) is a multiprotein complex that transcribes DNA into precursors of messenger RNA (mRNA) and most small nuclear RNA (snRNA) and microRNA. [1] [2] It is one of the three RNAP enzymes found in the nucleus of eukaryotic cells. [3] A 550 kDa complex of 12 subunits, RNAP II is the most studied type of RNA polymerase.
RNAP not only initiates RNA transcription, it also guides the nucleotides into position, facilitates attachment and elongation, has intrinsic proofreading and replacement capabilities, and termination recognition capability. In eukaryotes, RNAP can build chains as long as 2.4 million nucleotides.
Unwarranted variations in medical practice refer to the differences in care that cannot be explained by the illness/medical need or by patient preferences. The term “unwarranted variations” was first coined by Dr. John Wennberg when he observed small area (geographic) and practice style variations, which were not based on clinical rationale. [5]
Use of abbreviations, such as those relating to the route of administration or dose of a medication, can be confusing and is the most common source of medication errors. [2] Use of some acronyms has been shown to impact the safety of patients in hospitals, and "do not use lists" have been published at a national level in the US. [4]
Health workforce research is the investigation of how social, economic, organizational, political and policy factors affect access to health care professionals, and how the organization and composition of the workforce itself can affect health care delivery, quality, equity, and costs.
In eukaryote cells, RNA polymerase III (also called Pol III) is a protein that transcribes DNA to synthesize 5S ribosomal RNA, tRNA, and other small RNAs. The genes transcribed by RNA Pol III fall in the category of "housekeeping" genes whose expression is required in all cell types and most environmental conditions.
It is published by Lippincott Williams & Wilkins on behalf of the American College of Healthcare Executives. [1] Each issue prints an interview with a leading healthcare executive. The journal was established in 1956 as Hospital Administration, [2] and was renamed Hospital & Health Services Administration in 1976. [3] It took its current name ...