Search results
Results from the WOW.Com Content Network
Interleukin 3 (IL-3) is a protein that in humans is encoded by the IL3 gene localized on chromosome 5q31.1. [3] [4] Sometimes also called colony-stimulating factor, multi-CSF, mast cell growth factor, MULTI-CSF, MCGF; MGC79398, MGC79399: after removal of the signal peptide sequence, the mature protein contains 133 amino acids in its polypeptide chain.
The interleukin-3 receptor is a molecule found on cells which helps transmit the signal of interleukin-3, a soluble cytokine important in the immune system. The gene coding for the receptor is located in the pseudoautosomal region of the X and Y chromosomes .
Interleukin 3 (IL3) is a cytokine that regulates hematopoiesis by controlling the production, differentiation and function of granulocytes and macrophages. [ 15 ] [ 16 ] The protein, which exists in vivo as a monomer, is produced in activated T cells and mast cells, [ 15 ] [ 16 ] and is activated by the cleavage of an N-terminal signal sequence.
The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this ...
These receptors are commonly found on natural killer cells and some subpopulations of innate and adaptive cells. They are involved in activation and cytotoxic activity of NK cells, including cells lysis and secretion of pro-inflammatory cytokines. [ 3 ]
Interleukin receptors are a family of cytokine receptors for interleukins. They belong to the immunoglobulin superfamily. Types
Growth factor is sometimes used interchangeably among scientists with the term cytokine. [3] Historically, cytokines were associated with hematopoietic (blood and lymph forming) cells and immune system cells (e.g., lymphocytes and tissue cells from spleen, thymus, and lymph nodes).
Interleukin 13 (IL-13) is a protein that in humans is encoded by the IL13 gene. [ 4 ] [ 5 ] [ 6 ] IL-13 was first cloned in 1993 and is located on chromosome 5q31.1 with a length of 1.4kb. [ 4 ] It has a mass of 13 kDa and folds into 4 alpha helical bundles. [ 7 ]