Search results
Results from the WOW.Com Content Network
Interleukin 3 is an interleukin, a type of biological signal that can improve the body's natural response to disease as part of the immune system. [10] In conjunction with other β common chain cytokines GM-CSF and IL-5, IL-3 works to regulate the inflammatory response in order to clear pathogens by changing the abundance of various cell populations via binding at the interleukin-3 receptor.
The interleukin-3 receptor is a molecule found on cells which helps transmit the signal of interleukin-3, a soluble cytokine important in the immune system. The gene coding for the receptor is located in the pseudoautosomal region of the X and Y chromosomes .
T cells are one of the important types of white blood cells of the immune system and play a central role in the adaptive immune response. T cells can be distinguished from other lymphocytes by the presence of a T-cell receptor (TCR) on their cell surface. T cells are born from hematopoietic stem cells, [1] found in the bone marrow.
The T cells portray a type 1 immune response; however, the thickening and inflammation of the epidermis is thought to be caused by the production of IL-22, IL-17A, and IL-17F by other T cells such as Th17 or γδ T cells. [39]
Interleukin 10 (IL-10) is a protein that inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF, and GM-CSF produced by activated macrophages and by helper T cells. In structure, IL-10 is a protein of about 160 amino acids that contains four conserved cysteines involved in disulphide bonds. [ 33 ]
IL-17A specifically targets keratinocytes and is the major cytokine causing pathogenesis of skin psoriasis. [18] In addition, IL-17A is also expressed to an increasing extent in patients with inflammatory bowel disease. [19] ILC 3 may play a role already in the prenatal setting of the body's resistance to infections.
Type 1 interleukin receptors include: [1] [2] Interleukin-1 receptor; Interleukin-2 receptor; Interleukin-3 receptor; Interleukin-4 receptor; Interleukin-5 receptor; Interleukin-6 receptor; Interleukin-7 receptor; Interleukin-9 receptor; Interleukin-11 receptor; Interleukin-12 receptor; Interleukin-13 receptor; Interleukin-15 receptor ...
Lymphocyte-activation gene 3, also known as LAG-3, is a protein which in humans is encoded by the LAG3 gene. [5] LAG3, which was discovered in 1990 [6] and was designated CD223 (cluster of differentiation 223) after the Seventh Human Leucocyte Differentiation Antigen Workshop in 2000, [7] is a cell surface molecule with diverse biological effects on T cell function but overall has an immune ...