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Papaya extract Carica papaya: Warfarin Damage to GI tract mucous membranes [3] Kava: kava-kava Piper methysticum: Sedatives, sleeping pills, antipsychotics, alcohol [15] Milkvetch: Astragalus: Astragalus may interact with medications that suppress the immune system, such as cyclophosphamide. [24] It may also affect blood sugar levels and blood ...
Kava extract interacts with many pharmaceuticals and herbal medications. In human volunteers, in vivo inhibition includes CYP1A2 [ 5 ] and CYP2E1 [ 6 ] through use of probe drugs to measure inhibition.
The extract is an emulsion of kavalactone droplets in starch. The taste is slightly pungent, while the distinctive aroma depends on whether it was prepared from dry or fresh plant, and on the variety. The colour is grey to tan to opaque greenish. Kava prepared as described above is much more potent than processed kava.
Methysticin is one of the six major kavalactones found in the kava plant. [1] Research suggests that methysticin and the related compound dihydromethysticin have CYP1A1 inducing effects which may be responsible for their toxicity. [2]
Yangonin is one of the six major kavalactones found in the kava plant. [1] It has been shown to possess binding affinity for the cannabinoid receptor CB 1 (K i = 0.72 μM), and selectivity vs. the CB 2 receptor (K i >10 μM) where it behaves as an agonist.
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Flavokavain A is a flavokavain found in the kava plant. [1] It induces apoptosis in bladder cancer cells via a Bax protein-dependent and mitochondria-dependent apoptotic pathway. [2] Flavokavains A and B enhance hepatotoxicity of paracetamol, underscoring a potentially serious interaction between paracetamol and kava.
"Decreasing food-drug interactions can help make sure that your medications work properly." And for those die-hard grapefruit fans, all is not lost. Gans suggests exploring some alternatives: "The ...