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Aducanumab, sold under the brand name Aduhelm, is a monoclonal antibody designed to treat Alzheimer's disease. It is a monoclonal antibody that targets aggregated forms (plaque) of amyloid beta (Aβ) found in the brains of people with Alzheimer's disease to reduce its buildup. [10] It was developed by Biogen and Eisai. [11] Aducanumab is given via intravenous infusion. [5] Aducanumab was ...
Editor's note: A previous version of this article incorrectly stated that Eli Lilly's experimental drug solanezumab is a BACE inhibitor, and incorrectly noted the dates that Prana will release its ...
Alzheimer's disease (AD) is a neurodegenerative disease that usually starts slowly and progressively worsens. [2] It is the cause of 60–70% of cases of dementia. [2] [15] The most common early symptom is difficulty in remembering recent events. [1]
A current therapeutic target for the treatment of Alzheimer's disease is the protease β-secretase [80] [non-primary source needed], which is involved in the amyloidogenic processing pathway that leads to the pathological accumulation of proteins in the brain.
Alzheimer’s disease is not transmissible through the air, or by touching or being near someone with Alzheimer’s.” Still, he said the study’s findings weren’t entirely new.
Solanezumab was safely used in combination with approved Alzheimer's disease treatment, such as acetylcholinesterase inhibitors or memantine, in the clinical trials. [1] [7] [8] Aside from Alzheimer's disease, there are other amyloid beta related diseases, in which solanezumab could be used, e.g., Down syndrome or cerebral amyloid angiopathy. [9]
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