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Antidepressants with a lower half-life, such as paroxetine, duloxetine, and venlafaxine, have been implicated in higher incidences of withdrawal symptoms and more severe withdrawal symptoms. [25] With SSRIs, duration of treatment does not appear associated with the severity of withdrawal symptoms. [24]
What are SSRIs and what does SSRI stand for? SSRIs are a group of antidepressants known as selective serotonin reuptake inhibitors that work to prevent the brain from reabsorbing serotonin, a key ...
SSRIs are modern antidepressants often used as a first-line treatment for major depressive disorder. Common SSRIs include Prozac (fluoxetine), Zoloft (sertraline) and Lexapro (escitalopram ...
Long-term efficacy remains poorly characterized. Similar recommendations apply to binge eating disorder. [37] SSRIs provide short-term reductions in binge eating behavior, but have not been associated with significant weight loss. [38] Clinical trials have generated mostly negative results for the use of SSRIs in the treatment of anorexia ...
Symptoms typically persist for a longer time frame in patients taking drugs which have a long elimination half-life, active metabolites, or a protracted duration of action. [6] Cases have reported persisting chronic symptoms, [75] and antidepressant discontinuation may contribute to ongoing features. [76]
Antidepressants can include SSRIs (which increase serotonin levels in the brain), SNRIs (which increase serotonin and norepinephrine), and atypical antidepressants (Wellbutrin, for example), along ...
In some cases, switching from venlafaxine to fluoxetine, a long-acting SSRI, and then tapering off fluoxetine, may be recommended to reduce discontinuation symptoms. [84] [85] Signs and symptoms of withdrawal from abrupt cessation of an SNRI include dizziness, anxiety, insomnia, nausea, sweating, and flu-like symptoms, such as lethargy and malaise.
In general, large-scale studies do tend to show that long-term use of antidepressants is associated with weight gain side effects. However, study data on escitalopram and weight changes is very ...