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Many benzodiazepines (including midazolam) have longer half-lives than flumazenil. Therefore, in cases of overdose, repeated doses of flumazenil may be required to prevent recurrent symptoms once the initial dose of flumazenil wears off. [citation needed] It is hepatically metabolised to inactive compounds which are excreted in the urine.
Tricyclic antidepressant overdose is poisoning caused by excessive medication of the tricyclic antidepressant (TCA) type. Symptoms may include elevated body temperature , blurred vision, dilated pupils , sleepiness, confusion, seizures , rapid heart rate , and cardiac arrest . [ 1 ]
The antidote for an overdose of midazolam (or any other benzodiazepine) is flumazenil. [41] While effective in reversing the effects of benzodiazepines it is not used in most cases as it may trigger seizures in mixed overdoses and benzodiazepine dependent individuals. [60] [61] Symptoms of midazolam overdose can include: [60] [61]
[172] [173] The symptoms of a benzodiazepine overdose may include; drowsiness, slurred speech, nystagmus, hypotension, ataxia, coma, respiratory depression, and cardiorespiratory arrest. [ 170 ] A reversal agent for benzodiazepines exists, flumazenil (Anexate), itself belonging to the chemical class of benzodiazepines.
(Reuters) - A high-dose version of the opioid reversal spray naloxone, made by Hikma Pharmaceuticals, did not result in an increased survival rate compared with lower-dose versions of the drug ...
When Trea Ellinger left a Baltimore drug rehab facility last summer, he assured his anxious mother that everything was fine. He had his medications and was planning to meet up with his girlfriend.
The most common symptoms of overdose include central nervous system (CNS) depression, impaired balance, ataxia, and slurred speech. Severe symptoms include coma and respiratory depression. Supportive care is the mainstay of treatment of benzodiazepine overdose. There is an antidote, flumazenil, but its use is controversial. [2]
The Oregon Health Authority plans to offer free opioid overdose reversal kits to middle and high schools throughout the state, the agency said Tuesday.