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The mitotic index is a measure of cellular proliferation. [1] It is defined as the percentage of cells undergoing mitosis in a given population of cells. Mitosis is the division of somatic cells into two daughter cells. Durations of the cell cycle and mitosis vary in different cell types. An elevated mitotic index indicates more cells are dividing.
Mitotic trigger waves are waves of Cyclin-dependent kinase 1 activity in cells that originate from pacemaker regions of the nucleus and propagate through the cytoplasm. [1]. Because trigger waves do not decrease in speed or amplitude during their propagation, they are more reliable at conveying molecular information across greater distances ...
The centromeres of the chromosomes convene themselves on the metaphase plate, an imaginary line that is equidistant from the two spindle poles. [3] This even alignment is due to the counterbalance of the pulling powers generated by the opposing kinetochore microtubules, [ 4 ] analogous to a tug-of-war between two people of equal strength ...
Cells in the mitotic phase are identified by the typical appearance of their chromosomes in the cell during the mitotic phase of the cell cycle. [4] Usually the number of mitotic figures is expressed as the total number in a defined number of high power fields, such as 10 mitoses in 10 high power fields.
Cell synchronization is a process by which cells in a culture at different stages of the cell cycle are brought to the same phase. Cell synchrony is a vital process in the study of cells progressing through the cell cycle as it allows population-wide data to be collected rather than relying solely on single-cell experiments.
Many biological circuits produce complex outputs by exploiting one or more feedback loops. In a sequence of biochemical events, feedback would refer to a downstream element in the sequence (B in the adjacent image) affecting some upstream component (A in the adjacent image) to affect its own production or activation (output) in the future.
The cyclins are necessary for the kinase subunit to function with the appropriate substrate. The mitotic cyclins can be grouped as cyclins A & B. These cyclins have a nine residue sequence in the N-terminal region called the “destruction box”, which can be recognized by the ubiquitin ligase enzyme which destroys the cyclins when appropriate.
The Mad2 gene was first identified in the yeast S. cerevisiae in a screen for genes which when mutated would confer sensitivity to microtubule poisons. [1] The human orthologues of Mad2 ( MAD2L1 and MAD2L2 ) were first cloned in a search for human cDNAs that would rescue the microtubule poison-sensitivity of a yeast strain in which a ...