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Avanafil is a PDE5 inhibitor approved for erectile dysfunction by the FDA on April 27, 2012 [2] and by EMA on June 21, 2013. [3] Avanafil is sold under the brand names Stendra and Spedra .
Vivus developed an erectile dysfunction drug, Avanafil, that has completed Phase 3 clinical trials. [1] The drug has been approved for use by the FDA, and is sold under the trademark name Stendra. [2] Stendra is the first and only oral ED treatment approved to be taken approximately 15 minutes before sexual activity. [3]
Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.
The major PDE5 inhibitors (a subset of the phosphodiesterase inhibitors) are sildenafil, tadalafil, vardenafil, and avanafil, and although all share the same mechanism of action each has unique pharmacokinetic and pharmacodynamic properties which dictate their suitability in various conditions and their side effect profile.
Avanafil is the only fast-working FDA-tested and approved ED drug, despite the fast-acting male enhancements being pushed these days. When it comes to those herbal or dietary supplements you see ...
BP-101 – undefined mechanism of action (BP 101 - Ovoca Bio - AdisInsight); Bupropion/trazodone (S1P-104, S1P-205, Lorexys, Orexa) – norepinephrine reuptake inhibitor, nicotinic acetylcholine receptor antagonist, 5-HT 2A receptor antagonist, α 1-adrenergic receptor antagonist, weak serotonin reuptake inhibitor (Bupropion/trazodone - AdisInsight)
Avanafil (Stendra) All of these meds belong to a class of drugs called phosphodiesterase type 5 inhibitors, or PDE5 inhibitors. They’re vasodilators, meaning they improve blood flow to the ...
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