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1,3,7-Trimethyluric acid, also referred to as trimethyluric acid and 8-oxy-caffeine, is a purine alkaloid that is produced in some plants and occurs as a minor metabolite of caffeine in humans. [1] The enzymes that metabolize caffeine into 1,3,7-trimethyluric acid in humans include CYP1A2 , CYP2E1 , CYP2C8 , CYP2C9 , and CYP3A4 .
YouTube Rewind 2018 is the single most disliked video on YouTube, receiving over 19 million dislikes since its upload on December 6, 2018. [1]This list of most-disliked YouTube videos contains the top 42 videos with the most dislikes of all time, as derived from the American video platform, YouTube's, charts. [2]
"3, 2, 1" is a song by American singer 24kGoldn, released on February 19, 2021, as the third single from his debut studio album El Dorado (2021). The song was produced by Nick Mira , KC Supreme, Rio Leyva, Omer Fedi and Blake Slatkin.
"Kokomo" appeared on Blender ' s list of the 50 worst songs [98] and Dallas Observer ' s list of the ten worst songs by great artists. [99] MEL Magazine named it the worst summer song, and wrote that "a lot of us have taken immense delight in hating this 1988 smash". [100] NME named the "Kokomo" music video one of the worst ever. [101]
The music video for the song premiered on the MySpace main page January 16, 2009 [4] and was subsequently released on MTV, MTVU, VH1, Fuse, Music Choice and YouTube. [5] [6] [7] It found success on the weekly VH1 Top 20 Video Countdown, charting over five months straight between January and May, peaking at #5. It was listed on the VH1 Top 40 ...
"3-2-1" is a song recorded by Canadian country music artist Brett Kissel. It was released in February 2014 as the third single from his major label debut album, Started with a Song . [ 1 ] Kissel wrote the song with Marv Green and Tim Nichols .
"Down" is a song by the band 311. It is the first song on their third album, 311. It was their first #1 single on the Billboard Alternative Songs charts, and along with their self-titled album, was largely responsible for launching them into mainstream success. An accompanying video for the song was in rotation on MTV at the
"S.S.T." is a song by American musician Prince which was recorded and released directly after the impact of 2005's Hurricane Katrina. It was officially released as a digital download by the NPG Music Club on September 3, 2005, and reached number one on the iTunes R&B chart. It was later made available as a CD single through commercial outlets. [1]