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Developmental toxicity is any developmental malformation that is caused by the toxicity of a chemical or pathogen. It is the structural or functional alteration, reversible or irreversible, which interferes with homeostasis , normal growth , differentiation , development or behavior.
An early life stage (ELS) test is a chronic toxicity test using sensitive early life stages like embryos or larvae to predict the effects of toxicants on organisms. [1] ELS tests were developed to be quicker and more cost-efficient than full life-cycle tests, taking on average 1–5 months to complete compared to 6–12 months for a life-cycle test.
Teratology is the study of abnormalities of physiological development in organisms during their life span. It is a sub-discipline in medical genetics which focuses on the classification of congenital abnormalities in dysmorphology caused by teratogens and also in pharmacology and toxicology.
The Denver Developmental Screening Test (DDST) was introduced in 1967 to identify young children, up to age six, with developmental problems. A revised version, Denver II, was released in 1992 to provide needed improvements. These screening tests provide information about a range of ages during which normally developing children acquire certain ...
The Gesell Developmental Schedules are a set of developmental metrics which outline the ages & stages of development in young children developed by Dr. Arnold Gesell and colleagues. [1] The original scale is generally considered not to satisfy the standards of rigor currently accepted in the field of psychometrics and is no longer used as an ...
It was validated both at the hospital and the community level against the standard Denver Developmental Screening Test. [2]With a sensitivity of 66.7% and specificity of 78.8%, it can be used even by community level health worker for mass screening and takes around 5 minutes to complete. [2]
Category 1 has two subcategories for reproductive and developmental effects. Materials which cause concern for the health of breastfed children have a separate category: effects on or via Lactation. Specific target organ toxicity (STOT) [8] category distinguishes between single and repeated exposure for Target Organ Effects. All significant ...
Toxicology testing is commonly conducted during preclinical development for a substance intended for human exposure. Stages of in silico, in vitro and in vivo research are conducted to determine safe exposure doses in model organisms. If necessary, the next phase of research involves human toxicology testing during a first-in-man study.