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In a major injury, if epithelial cell migration and tissue contraction cannot cover the wound, suturing the edges of the injured skin together, or even replacement of lost skin with skin grafts, may be required to restore the skin. As epithelial cells continue to migrate around the scab, the dermis is repaired by the activity of stem cells.
Contraction is a key phase of wound healing with repair. If contraction continues for too long, it can lead to disfigurement and loss of function. [32] Thus there is a great interest in understanding the biology of wound contraction, which can be modelled in vitro using the collagen gel contraction assay or the dermal equivalent model. [27] [53]
Maceration is defined as the softening and breaking down of skin resulting from prolonged exposure to moisture. It was first described by Jean-Martin Charcot in 1877. [1] [2] Maceration is caused by excessive amounts of fluid remaining in contact with the skin or the surface of a wound for extended periods.
Skin grafting, a type of graft surgery, involves the transplantation of skin without a defined circulation. The transplanted tissue is called a skin graft. [1] Surgeons may use skin grafting to treat: extensive wounding or trauma; burns; areas of extensive skin loss due to infection such as necrotizing fasciitis or purpura fulminans [2]
Kristi Ledgerwood was diagnosed with type 2 diabetes and lost 210 pounds with walking, low-carb diet. She had skin-removal surgery to remove loose skin after weight loss.
Chronic wounds take a long time to heal and patients can experience chronic wounds for many years. [43] Chronic wound healing may be compromised by coexisting underlying conditions, such as venous valve backflow , peripheral vascular disease , uncontrolled edema and diabetes mellitus .
Cole Prochaska lost 360 pounds by walking, eating a high-protein diet and lifting weights. But he feels trapped by his loose skin after his weight loss.
TLC Skin Tight is a TV show with each episode following “two people who have lost massive amounts of weight and are about to undergo a full body transformation through skin removal surgery.” [6] “It’s not unusual, says the show, for there to be “up to 50 pounds” of sagging skin following massive weight loss. Skin Tight ran for three ...