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It is an aromatic amine. It is a component of a test for cyanide. ... Benzidine has been linked to bladder and pancreatic cancer. [2] Synthesis and properties
A positive test indicates that the chemical is mutagenic and therefore may act as a carcinogen, because cancer is often linked to mutation. The test serves as a quick and convenient assay to estimate the carcinogenic potential of a compound because standard carcinogen assays on mice and rats are time-consuming (taking two to three years to ...
Similar results are also obtained in ... Ames test – This is the most ... incidence of bladder cancer among workers in German synthetic aromatic amine dye ...
PhIP (2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) is one of the most abundant heterocyclic amines (HCAs) in cooked meat. PhIP is formed at high temperatures from the reaction between creatine or creatinine (found in muscle meats), amino acids, and sugar.
4,4′-Methylenebis(2-chloroaniline) (also known as MOCA, MBOCA, and bisamine) is a substance used as a curing agent in polyurethane production. [3] MOCA is an aromatic amine which is structurally similar to benzidine, a known human bladder carcinogen.
These are also known as "indirect-acting" carcinogens. Examples of activation-dependent carcinogens include polycyclic aromatic hydrocarbons (PAHs), heterocyclic aromatic amines, and mycotoxins. Activation-independent carcinogens, or "direct-acting" carcinogens, are those that are capable of directly damaging DNA without any modification to ...
Seed oils — plant-based cooking oils often used in processed, packaged foods — have been linked to an increased risk of colon cancer, according to a new study published in the medical journal Gut.
This compound has been a major research area for cancer-causing agents. 2-Acetylaminofluorene is able to cause tumors in mice and other animals in the liver and kidney. This substance can act as a substrate for cytochrome P450 (CYP). In this lock and key conformation, the enzyme will allow for a hydroxyl group to be added onto the 2nd carbon of ...