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Lithium orotate (C 5 H 3 LiN 2 O 4) is a salt of orotic acid and lithium.It is available as the monohydrate, LiC 5 H 3 N 2 O 4 ·H 2 O. [1] In this compound, lithium is non-covalently bound to an orotate ion, rather than to a carbonate or other ion, and like other salts, dissolves in solution to produce free lithium ions.
Lithium is a teratogen, which can cause birth defects in a small number of newborns. Case reports and several retrospective studies have demonstrated possible increases in the rate of a congenital heart defects including Ebstein's anomaly if taken during pregnancy. Teratogenicity is affected by trimester and dose of Lithium.
Orotic acid is a Bronsted acid and its conjugate base, the orotate anion, is able to bind to metals. Lithium orotate, for example, has been investigated for use in treating alcoholism, [4] [5] and complexes of cobalt, manganese, nickel, and zinc are known. [6]
Lithium – Lithium is the "classic" mood stabilizer, the first to be approved by the US FDA, and still popular in treatment. Therapeutic drug monitoring is required to ensure lithium levels remain in the therapeutic range: 0.6 to 0.8 or 0.8–1.2 mEq/L (or millimolar).
In addition, the drug dose-dependently increases hippocampal volume in mice. [1] [12] In one study, there was an approximate 36% increase at 10 mg/kg and an approximate 66% increase at 30 mg/kg. [12] [31] There appears to be a bell-shaped dose–response curve, with 100 mg/kg being less effective than 30 mg/kg in stimulating hippocampal volume.
For the record: 7:04 a.m. Oct. 28, 2024: An earlier version of this article said a lithium-ion battery fire occurred on Interstate 15 near Bakersfield.It was near Baker. For more than two days, a ...
Lithium coin batteries, those small, disc-shaped batteries about the size of a nickel, are particularly dangerous. The exact right size to get lodged in a child's throat if accidentally swallowed ...
Hanging baskets may not be the first thing you think of for providing a safe place for birds but they are a protected area for birds to create a nest. "As a child, one of my favorite memories was ...
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