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Photolabile protecting groups bear a chromophore, which is activated through radiation with an appropriate wavelength and so can be removed. [6] For examples the o-nitrobenzylgroup ought be listed here. The rare double-layer protecting group is a protected protecting group, which exemplify high stability.
Benzyl group and derivatives: Benzyl group, benzyl radical, benzyl amine, benzyl bromide, benzyl chloroformate, and benzyl methyl ether. R = heteroatom, alkyl, aryl, allyl etc. or other substituents. In organic chemistry, benzyl is the substituent or molecular fragment possessing the structure R−CH 2 −C 6 H 5.
In organic chemistry, benzoyl (/ ˈ b ɛ n z oʊ ɪ l /, BENZ-oh-il) [1] is the functional group with the formula −COC 6 H 5 and structure −C(=O)−C 6 H 5. [2] [3] It can be viewed as benzaldehyde missing one hydrogen. The benzoyl group has a mass of 105 amu. The term "benzoyl" should not be confused with benzyl, which has the formula − ...
The isocyanate in turn reacts with benzyl alcohol to form a benzylurethane (also referred to as carboxybenzyl), a compound possessing a carbamate amine protecting group. [1] [3] Subsequent removal of the carbamate protecting group is carried out by catalytic hydrogenation in the presence of hydrochloric acid followed by addition to boiling ...
Permanent side-chain protecting groups used during Boc/benzyl SPPS are typically benzyl or benzyl-based groups. [1] Final removal of the peptide from the solid support occurs simultaneously with side chain deprotection using anhydrous hydrogen fluoride via hydrolytic cleavage. The final product is a fluoride salt which is relatively easy to ...
A photolabile protecting group (PPG; also known as: photoremovable, photosensitive, or photocleavable protecting group) is a chemical modification to a molecule that can be removed with light. PPGs enable high degrees of chemoselectivity as they allow researchers to control spatial, temporal and concentration variables with light.
Benzyl chloroformate is commonly used in organic synthesis for the introduction of the benzyloxycarbonyl (formerly called carboxybenzyl) protecting group for amines.The protecting group is abbreviated Cbz or Z (in honor of discoverer Zervas), hence the alternative shorthand designation for benzyl chloroformate as Cbz-Cl or Z-Cl.
Scheme for dehalogenation reaction (R = alkyl or aryl group, X = I, Cl, Br, F) In organic chemistry, dehalogenation is a set of chemical reactions that involve the cleavage of carbon-halogen bonds; as such, it is the inverse reaction of halogenation.