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The most frequent liver cancer, accounting for approximately 75% of all primary liver cancers, is hepatocellular carcinoma (HCC). [15] HCC is a cancer formed by liver cells, known as hepatocytes, that become malignant. In terms of cancer deaths, worldwide HCC is considered the 3rd most common cause of cancer mortalities. [16]
Hepatocytes constitute about 80% of the cell population of the liver, with the other 20% being occupied by Kupffer cells, hepatic stellate cells, endothelial cells and mesothelial cells, which are not exactly characteristic of the liver, but are present in the liver samples. [2] Histologically speaking, hepatocytes have specific characteristics.
Like hepatic adenomas, they are diagnosed with imaging and biopsies as needed. Treatment of liver cell adenomatosis is difficult due to the multiple, widespread lesions. Liver imaging should be reviewed to see if it is possible to surgically remove the tumors. [7] Liver transplantation is a treatment option for some patients. [7]
Radiation therapy is used to kill cancer cells; however, normal cells are also damaged in the process. Currently, therapeutic doses of radiation can be targeted to tumors with great accuracy using linear accelerators in radiation oncology; however, when irradiating using external beam radiotherapy, the beam will always need to travel through healthy tissue, and the normal liver tissue is very ...
Clear evidence establishes ultraviolet radiation, especially the non-ionizing medium wave UVB, as the cause of most non-melanoma skin cancers, which are the most common forms of cancer in the world. [40] Skin cancer may occur following ionizing radiation exposure following a latent period averaging 20 to 40 years.
[15] [16] [17] However, the LKB1 gene was also found to be mutated in lung cancer of sporadic origin, predominantly adenocarcinomas. [18] Further, more recent studies have uncovered a large number of somatic mutations of the LKB1 gene that are present in cervical, breast, [ 11 ] intestinal, testicular, pancreatic and skin cancer.
In medicine, proton therapy, or proton radiotherapy, is a type of particle therapy that uses a beam of protons to irradiate diseased tissue, most often to treat cancer.The chief advantage of proton therapy over other types of external beam radiotherapy is that the dose of protons is deposited over a narrow range of depth; hence in minimal entry, exit, or scattered radiation dose to healthy ...
The typical hepatocyte is cubical with sides of 20-30 μm, (in comparison, a human hair has a diameter of 17 to 180 μm). [1] The typical volume of a hepatocyte is 3.4 x 10 −9 cm 3. [2] Smooth endoplasmic reticulum is abundant in hepatocytes, in contrast to most other cell types. [3]