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Androsterone, or 3α-hydroxy-5α-androstan-17-one, is an endogenous steroid hormone, neurosteroid, and putative pheromone. [1] It is a weak androgen with a potency that is approximately 1/7 that of testosterone . [ 2 ]
Allopregnanolone, a major endogenous inhibitory neurosteroid. Steroid ring system.. This is a list of neurosteroids, or natural and synthetic steroids that are active on the mammalian nervous system through receptors other than steroid hormone receptors.
The neurosteroid ganaxolone, an analog of the progesterone metabolite allopregnanolone, has been extensively investigated in animal models and is currently in clinical trials for the treatment of epilepsy. Neurosteroids, including ganaxolone have a broad spectrum of activity in animal models. [46]
Dehydroepiandrosterone (δ 5-androsten-3β-ol-17-one) – an endogenous androgen, neurosteroid, agonist of PPARα, PXR, and CAR, and testosterone intermediate Androstadienes [ edit ]
[4] [8] [9] However, DHEA also has a variety of potential biological effects in its own right, binding to an array of nuclear and cell surface receptors, [10] and acting as a neurosteroid and modulator of neurotrophic factor receptors. [11] In the United States, DHEA is sold as an over-the-counter supplement, and medication called prasterone.
This is a list of androgens/anabolic steroids (AAS) or testosterone derivatives. Androgen esters are mostly not included in this list. The major classes of testosterone derivatives include the following (as well as combinations thereof):
3α-Androstanediol is an inhibitory androstane neurosteroid and weak androgen and estrogen. [1] [2] [3]As a neurosteroid, it acts as a potent positive allosteric modulator of the GABA A receptor, [4] and has been found to have rewarding, [5] [6] anxiolytic, [7] pro-sexual, [8] and anticonvulsant effects.
Androstanedione is a 5α-reduced metabolite of 4-androstenedione which serves as an intermediate in the biosynthesis of the androgen and neurosteroid androsterone. [9] Androstenedione also has a variety of metabolites in different species. In cattle, androstenedione is converted into oestradiol-17 and epitestosterone. [10]