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Hyperandrogenism, especially high levels of testosterone, can cause serious adverse effects if left untreated. High testosterone levels are associated with other health conditions such as obesity, hypertension, amenorrhea (cessation of menstrual cycles), and ovulatory dysfunction, which can lead to infertility.
When given as long-acting implants, these cause “medical castration,” that is, the complete suppression of reproductive activity and the suppression of sex steroids. They have been shown to be effective in both dogs and cats. Compounds that bind and block the GnRH receptor can also cause suppression of fertility and sex steroids.
The free androgen index is intended to give a guide to the free testosterone level, but it is not very accurate (especially in males — see endocrine society commentary below). Consequently, there are no universally agreed 'normal ranges', and levels slightly above or below quoted laboratory reference ranges may not be clinically significant.
But when considering calculated free testosterone, luteinizing hormones, and sex hormone-binding globulin levels, up to 20.2 percent of men would qualify as having subsets of the condition, like ...
Signs of hyperestrogenism may include heightened levels of one or more of the estrogen sex hormones (usually estradiol and/or estrone), lowered levels of follicle-stimulating hormone and/or luteinizing hormone (due to suppression of the hypothalamic–pituitary–gonadal axis by estrogen), and lowered levels of androgens such as testosterone (generally only relevant to males). [1]
The cause of this is not well understand but it's generally thought to be something to do with serotonin. Gut microbes modulate about 60% of your serotonin so that you can use it, and antibiotics ...
Aromatase excess syndrome (AES or AEXS) is a rarely diagnosed genetic and endocrine syndrome which is characterized by an overexpression of aromatase, the enzyme responsible for the biosynthesis of the estrogen sex hormones from the androgens, in turn resulting in excessive levels of circulating estrogens and, accordingly, symptoms of hyperestrogenism.
Increased levels of these hormones will cause the body to not start puberty, not undergo menarche, and not develop secondary sex characteristics. [9] [10] If ovarian tissue is present and produces some amount of hormones, limited menstrual cycles can occur. [9] 46,XX gonadal dysgenesis can manifest from a variety of causes. [6]