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Gestational diabetes, which occurs in humans and dogs, has never been found in cats. [2] Insulin resistance and diabetes in cats can also have a component of hypersomatotropism (an excess of growth hormone, also leading to acromegaly) [3] and hyperadrenocorticism. [4] In some cats, cancer causes the loss of pancreatic islets. [3]
Hyperandrogenism, especially high levels of testosterone, can cause serious adverse effects if left untreated. High testosterone levels are associated with other health conditions such as obesity, hypertension, amenorrhea (cessation of menstrual cycles), and ovulatory dysfunction, which can lead to infertility.
High estrogen and thyroxine levels cause it to increase. In an effort to explain obesity-related reductions in SHBG, recent evidence suggests sugar or monosaccharide-induced hepatic lipogenesis, hepatic lipids in general, and cytokines like TNF-alpha and interleukins reduce SHBG, whereas insulin does not.
Conversely, “with too much testosterone, women often have acne, too much hair on the body, hair loss on the head, high blood pressure, elevated cholesterol, skipped cycles, or problems ...
Research shows that older men and women with low testosterone have lower red blood cell counts and an increased risk of developing anemia. Anemia can produce symptoms like fatigue, weakness, loss ...
Researchers say higher testosterone levels in men under age 65 who are overweight or have obesity can help lower the risk of developing type 2 diabetes
However, free testosterone is difficult and expensive to measure (it requires a time-consuming dialysis step), and many laboratories do not offer this service. The free androgen index is intended to give a guide to the free testosterone level, but it is not very accurate (especially in males — see endocrine society commentary below).
Aromatase excess syndrome (AES or AEXS) is a rarely diagnosed genetic and endocrine syndrome which is characterized by an overexpression of aromatase, the enzyme responsible for the biosynthesis of the estrogen sex hormones from the androgens, in turn resulting in excessive levels of circulating estrogens and, accordingly, symptoms of hyperestrogenism.
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