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Quaternary structure of the CD123 protein. The interleukin-3 receptor is a molecule found on cells which helps transmit the signal of interleukin-3, a soluble cytokine important in the immune system. The gene coding for the receptor is located in the pseudoautosomal region of the X and Y chromosomes.
pergolide – dopamine receptor agonist used for the treatment of pituitary pars intermedia dysfunction in horses; phenobarbital – anti-convulsant used for seizures; phenylbutazone – nonsteroidal anti-inflammatory drug (NSAID) phenylpropanolamine – controls urinary incontinence in dogs
3563 16188 Ensembl ENSG00000185291 ENSMUSG00000068758 UniProt P26951 P26952 RefSeq (mRNA) NM_001267713 NM_002183 NM_008369 RefSeq (protein) NP_001254642 NP_002174 NP_032395 Location (UCSC) Chr X: 1.34 – 1.38 Mb Chr 14: 8.11 – 8.12 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interleukin 3 receptor, alpha (low affinity) (IL3RA), also known as CD123 (C luster of D ifferentiation ...
Lokivetmab, trade name Cytopoint, is a monoclonal antibody used to treat atopic dermatitis in dogs. [1] It acts against interleukin 31 (IL-31), [2] which is a cytokine involved in causing itchiness (pruritus). [2] Lokivetmab is administered by subcutaneous injection; each dose is effective for four to eight weeks. [3]
Imepitoin acts as a low-affinity (4,350–5,140 nM; relative to K i = 6.8 nM for diazepam and K i = 1.7 nM for clonazepam) partial agonist of the benzodiazepine site of the GABA A receptor (up to 12–21% of the maximal potentiation of diazepam, a full agonist of this site). [1] It is the first partial agonist to be approved for the treatment ...
Half the dogs received bedinvetmab and half the dogs received a sterile saline injection every 28 days for a total of three doses. [5] Before treatment and on various days throughout the study, owners used the Canine Brief Pain Inventory (CBPI) assessment tool to measure the severity of the dog's pain and the degree to which the pain interfered ...
Oclacitinib, sold under the brand name Apoquel among others, is a veterinary medication used in the control of atopic dermatitis and pruritus from allergic dermatitis in dogs at least 12 months of age. [1] [4] Chemically, it is a synthetic cyclohexylamino pyrrolopyrimidine janus kinase inhibitor that is relatively selective for JAK1. [5]
Trimetaphan camsilate or trimethaphan camsylate (), trade name Arfonad, is a sympatholytic drug used in rare circumstances to lower blood pressure.. Trimetaphan is a ganglionic blocker: it counteracts cholinergic transmission at a specific type of nicotinic acetylcholine receptors in the autonomic ganglia and therefore blocks both the sympathetic nervous system and the parasympathetic nervous ...