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The A1 component then binds to the ribosome, disrupting protein synthesis. Stx-2 has been found to be about 400 times more toxic (as quantified by LD 50 in mice) than Stx-1. Gb3 is, for unknown reasons, present in greater amounts in renal epithelial tissues, to which the renal toxicity of Shiga toxin may be attributed.
Climate change is altering the geographic range and seasonality of some insects that can carry diseases, for example Aedes aegypti, the mosquito that is the vector for dengue transmission. Global climate change has increased the occurrence of some infectious diseases. Infectious diseases whose transmission is impacted by climate change include, for example, vector-borne diseases like dengue ...
The oral LD50 for humans is 5.7 μg/kg, therefore approximately 0.57 mg of saxitoxin is lethal if ingested and the lethal dose by injection is about one-tenth of that (approximately 0.6 μg/kg). The human inhalation toxicity of aerosolized saxitoxin is estimated to be 5 mg·min/m 3. Saxitoxin can enter the body via open wounds and a lethal dose ...
Climate change is making heat waves more intense, potentially leading to a higher risk of heat stroke. The effects of climate change on human health are profound because they increase heat-related illnesses and deaths, respiratory diseases, and the spread of infectious diseases. There is widespread agreement among researchers, health ...
Some climate change effects: wildfire caused by heat and dryness, bleached coral caused by ocean acidification and heating, environmental migration caused by desertification, and coastal flooding caused by storms and sea level rise. Effects of climate change are well documented and growing for Earth's natural environment and human societies. Changes to the climate system include an overall ...
Climate change is driving extreme weather By all accounts, the last few years have been brutal for the climate — and for the humans and other living things within it. Around the globe, heat ...
Survival of Parelaphostrongylus tenuis, a brain worm of white-tailed deer that affects moose, could be increased due to the higher temperatures and milder winters that are caused by climate change. In moose, this brain causes neurological disease and eventually ends up being fatal. Moose are already facing heat stress due to climate change, and ...
Syntaxin-2, also known as epimorphin, is a protein that in humans is encoded by the STX2 gene. [5] [6] [7] The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles.
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