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Tusi (also written as tussi, tuci, or tucibi) is a recreational drug that contains a mixture of different psychoactive substances, most commonly found in a pink-dyed powder known as pink cocaine. [ 1 ] [ 2 ] [ 3 ] It is believed to have originated in Latin America around 2018. [ 4 ]
Stimulant use disorder is a type of substance use disorder where the use of stimulants caused clinically significant impairment or distress. It is defined in the DSM-5 as "the continued use of amphetamine-type substances, cocaine, or other stimulants leading to clinically significant impairment or distress, from mild to severe". [1]
Dimethocaine is often abused as a legal substitute for cocaine. The drug is administered intravenously or nasally, because ingestion would lead to rapid hydrolyzation. [5] Its positive effects are euphoria, stimulation, increased talkativeness and mood lift. [6] However, because the drug acts similar as cocaine, it has comparable negative side ...
These drugs inhibit the uptake of the neurotransmitter 5-HT by blocking the SERT, thus increasing its synaptic concentration, and have shown to be efficacious in the treatment of depression, however sexual dysfunction and weight gain are two very common side-effects that result in discontinuation of treatment.
Amid public health warnings about rising stimulant use disorders, the Food and Drug Administration is urging drugmakers to develop treatments for cocaine and methamphetamine addiction.
The headline-making drug "pink cocaine" has been mentioned in the ongoing Sean "Diddy" Combs sex trafficking case and was linked to the death of One Direction star Liam Payne
The drug increases inhibitory GABAergic tone and causes neuro-inhibition of the cortical and limbic systems, observed clinically as a sedative-hypnotic effect. [162] Glutethimide is also a potent inducer of the CYP 2D6 enzyme in the liver. This enzyme is responsible for converting many drugs, from beta blockers to antidepressants to opioids and ...
[3] [4] [5] Methamphetamine psychosis, or long-term effects of stimulant use in the brain (at the molecular level), depend upon genetics and may persist for months or years. [6] Psychosis may also result from withdrawal from stimulants, particularly when psychotic symptoms were present during use. [7]