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Zonisamide is an antiseizure drug chemically classified as a sulfonamide and unrelated to other antiseizure agents. The precise mechanism by which zonisamide exerts its antiseizure effect is unknown, although it is believed that the drug blocks sodium and T-type calcium channels , which leads to the suppression of neuronal hypersynchronization ...
Levodopa was first synthesized in 1911 by Torquato Torquati from the Vicia faba bean. [3] It was first isolated in 1913 by Marcus Guggenheim from the V. faba bean. [3] Guggenheim tried levodopa at a dose of 2.5 mg and thought that it was inactive aside from nausea and vomiting. [3]
l-DOPA, also known as l-3,4-dihydroxyphenylalanine and used medically as levodopa, is made and used as part of the normal biology of some plants [2] and animals, including humans. Humans, as well as a portion of the other animals that utilize l -DOPA, make it via biosynthesis from the amino acid l -tyrosine .
Safinamide is used to treat idiopathic Parkinson's disease as add-on for people taking a stable dose of levodopa (L-dopa) alone or in combination with other Parkinson drugs, to help with "off" episodes when levodopa stops working. [4] [5] [7]
DopAmide, or L-DopAmide, is a synthetic levodopa (L-DOPA) analogue that can serve as a levodopa and dopamine prodrug and is of potential interest in the treatment of Parkinson's disease. [ 1 ] [ 2 ] [ 3 ] DopAmide has an amide rather than the carboxyl group of L -DOPA, [ 2 ] [ 3 ] which imparts greater water solubility .
New research suggests that drinking sparkling water can help support weight loss through satiety and energy production. Researcher Akira Takanashi of Japan and nutrition experts shared thoughts.
Today's Connections Game Answers for Wednesday, February 12, 2025: 1. DOCUMENTS OF OWNERSHIP: CERTIFICATE, DEED, RECEIPT, TITLE 2. BITS IN A VARIETY SHOW: DANCE ...
COMT inhibitors prevent the conversion of levodopa to 3-O-methyldopa. A catechol-O-methyltransferase inhibitor (COMT inhibitor) is a drug that inhibits the enzyme catechol-O-methyltransferase. This enzyme methylates catecholamines such as dopamine, norepinephrine and epinephrine. It also methylates levodopa.
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