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Synthetic oxytocin, sold under the brand name Pitocin among others, is a medication made from the peptide oxytocin. [6] [7] As a medication, it is used to cause contraction of the uterus to start labor, increase the speed of labor, and to stop bleeding following delivery. [6]
The hormone oxytocin has been identified as inducing uterine contractions, and labour in general. [9] Oxytocin is produced by the body naturally and since the 1950s has also been available in synthetic pharmaceutical form. [10] [11] In either form, oxytocin stimulates uterine contractions to accelerate the process of childbirth.
Similar to oxytocin, analogues bind to oxytocin receptors found along the muscles of the uterus and act as an agonist. During pregnancy, the number of oxytocin receptors increase until reaching their peak near completion of the pregnancy. An important note is that not all analogs of oxytocin work as an receptor agonist or as a uterotonic.
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Sucking causes the pituitary gland to release oxytocin, which contracts the uterus and prevents bleeding. [1] [6] This can be felt by the mother in the breasts. The crying of the infant can also induce the release of oxytocin. Cracked nipples can develop at this time, which can be managed with pharmacological and nonpharmacological treatment. [4]
In addition to the cardiovascular risk factors, hypertension can also severely impact kidney function, sexual health and eye health, and increase the risk of dementia. What causes high blood pressure?
It is released in response to an increase in oxytocin levels in the uterus, and stimulates both luteolytic activity and the release of oxytocin. [6] Because PGF 2α is linked with an increase in uterine oxytocin levels, there is evidence that PGF 2α and oxytocin form a positive feedback loop to facilitate the degradation of the corpus luteum. [7]