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  2. Biology of depression - Wikipedia

    en.wikipedia.org/wiki/Biology_of_depression

    The serotonin "chemical imbalance" theory of depression, proposed in the 1960s, [38] is not supported by the available scientific evidence. [ 38 ] [ 39 ] SSRIs alter the balance of serotonin inside and outside of neurons: their clinical antidepressant effect (which is robust in severe depression [ 40 ] ) is likely due to more complex changes in ...

  3. Depression is likely not caused by a chemical imbalance in ...

    www.aol.com/depression-likely-not-caused...

    For years, a chemical imbalance of serotonin has been widely viewed as the culprit for depression, resulting in the widespread use of antidepressants. The study published this week in the journal…

  4. Biopsychiatry controversy - Wikipedia

    en.wikipedia.org/wiki/Biopsychiatry_controversy

    The chemical imbalance hypothesis states that a chemical imbalance within the brain is the main cause of psychiatric conditions and that these conditions can be improved with medication that corrects this imbalance. In that, emotions within a "normal" spectrum reflect a proper balance of neurotransmitter function.

  5. The Emperor's New Drugs - Wikipedia

    en.wikipedia.org/wiki/The_Emperor's_New_Drugs

    The Emperor's New Drugs: Exploding the Antidepressant Myth is a 2009 book by Irving Kirsch, arguing that the chemical imbalance theory of depression is wrong and that antidepressants have little or no direct effect on depression but, because of their common or serious side-effects, they are powerful active placebos.

  6. Joanna Moncrieff - Wikipedia

    en.wikipedia.org/wiki/Joanna_Moncrieff

    Together with Dr. Mark Horowitz, Moncrieff in 2022 conducted the first [citation needed] systematic umbrella review of the evidence for the serotonin "chemical imbalance" theory of depression, which suggests that the evidence does not support the hypothesis. [22] [23]

  7. Endogenous depression - Wikipedia

    en.wikipedia.org/wiki/Endogenous_depression

    Indeed, this view of endogenous depression is at the root of the popular view that mood disorders are a reflection of a 'chemical imbalance' in the brain. More recent research has shown that the probability of an endogenous depression patient experiencing an adverse life event prior to a depressive episode is roughly the same as for a reactive ...

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