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Shorter courses of therapy in turn reduce the effects of dose-related toxicity, if applicable. [3] Additionally, synergy aids in total bacterial eradication, more completely removing an infection than would be possible without synergy. [2] At a higher level, synergistic effects are useful for combating resistant bacterial strains through ...
The treatment for another common disease, primary hypercholesterolemia, also demonstrates additive effect. Plant sterol-ester margarine and a common type of antihyperlipidaemic drug, cerivastatin , have an additive effect in reducing LDL cholesterol , without significant interaction between the two drugs. [ 28 ]
Pharmacotherapy, also known as pharmacological therapy or drug therapy, is defined as medical treatment that utilizes one or more pharmaceutical drugs to improve ongoing symptoms (symptomatic relief), treat the underlying condition, or act as a prevention for other diseases (prophylaxis).
Refers to the effects of treatment with a drug. If the effects change when the dose of the drug is changed, the effects are said to be dose-dependent. (NCI) Dose-limiting Describes side effects of a drug or other treatment that are serious enough to prevent an increase in dose or level of that treatment. (NCI) Dose-ranging study
This concept of three-drug therapy was quickly incorporated into clinical practice and rapidly showed impressive benefit with a 60% to 80% decline in rates of AIDS, death, and hospitalization. [2] It would also create a new period of optimism at the 11th International AIDS Conference that was held in Vancouver that year. [128]
Sometimes, the term antibiotic—literally "opposing life", from the Greek roots ἀντι anti, "against" and βίος bios, "life"—is broadly used to refer to any substance used against microbes, but in the usual medical usage, antibiotics (such as penicillin) are those produced naturally (by one microorganism fighting another), whereas non ...
A therapeutic index does not consider drug interactions or synergistic effects. For example, the risk associated with benzodiazepines increases significantly when taken with alcohol, [ 18 ] [ 19 ] [ 20 ] depressants, [ 18 ] opiates, [ 19 ] [ 21 ] [ 22 ] [ 20 ] [ 23 ] or stimulants [ 24 ] when compared with being taken alone.
The treatment is usually a drug, ionizing radiation, or a combination of the two. [8] Some current research studies the potentiation of drug effects by concurrent irradiation—a synergistic effect—and in this situation two groups are studied: a control group, which is not treated with the drug; and a treatment group, which is treated with the drug.