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A further study, the NHS Comparison Arm for ProtecT (CAP), as part of the Prostate testing for cancer and Treatment (ProtecT) study, randomized GP practices with 460,000 men aged 50–69 at centers in 9 cities in Britain from 2001–2005 to usual care or prostate cancer screening with PSA (biopsy if PSA ≥ 3). [65]
Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), P-30 antigen, is a glycoprotein enzyme encoded in humans by the KLK3 gene.PSA is a member of the kallikrein-related peptidase family and is secreted by the epithelial cells of the prostate gland in men and the paraurethral glands in women.
Prostate cancer is the uncontrolled growth of cells in the prostate, a gland in the male reproductive system below the bladder.Abnormal growth of the prostate tissue is usually detected through screening tests, typically blood tests that check for prostate-specific antigen (PSA) levels.
PSA levels between 4 and 10 suggest you could have about a 25 percent chance of prostate cancer, and levels over 10 signal that your chance of having the cancer is more than 50 percent.
Prostate specific antigen (PSA) 40–49 years: 1.2–2.9 [75] μg/L [5] [15] or ng/mL [23] More detailed cutoffs in PSA – Serum levels: 70–79 years, non-African-American: 4.0–9.0 [75] 70–79 years, African-American: 7.7–13 [75] PAP: 3 [23] units/dL (Bodansky units) Calcitonin: 5, [76] 15 [76] ng/L or pg/mL: Cutoff against medullary ...
However, checking blood PSA levels for prostate cancer screening is controversial and not necessarily indicated in every evaluation for BPH. [2] Benign prostatic hyperplasia and prostate cancer are both capable of increasing blood PSA levels and PSA elevation is unable to differentiate these two conditions well. [2]
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