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Hypoxemia refers to insufficient oxygen in the blood. Thus any cause that influences the rate or volume of air entering the lungs (ventilation) or any cause that influences the transfer of air from the lungs to the blood may cause hypoxemia. As well as these respiratory causes, cardiovascular causes such as shunts may also result in hypoxemia.
Hypoxia can be due to external causes, when the breathing gas is hypoxic, or internal causes, such as reduced effectiveness of gas transfer in the lungs, reduced capacity of the blood to carry oxygen, compromised general or local perfusion, or inability of the affected tissues to extract oxygen from, or metabolically process, an adequate supply ...
Oxygen therapy may be used to assist in raising blood oxygen levels. Oxygenation occurs when oxygen molecules (O 2) enter the tissues of the body. For example, blood is oxygenated in the lungs, where oxygen molecules travel from the air and into the blood. Oxygenation is commonly used to refer to medical oxygen saturation.
Restoration of blood supply to ischemic tissues can cause additional damage known as reperfusion injury that can be more damaging than the initial ischemia. Reintroduction of blood flow brings oxygen back to the tissues, causing a greater production of free radicals and reactive oxygen species that damage cells.
Arteries are blood vessels that carry oxygenated blood to body tissues. [ 1 ] [ 2 ] An occlusion of arteries disrupts oxygen and blood supply to tissues, leading to ischemia . [ 1 ] Depending on the extent of ischemia, symptoms of arterial occlusion range from simple soreness and pain that can be relieved with rest, [ 3 ] to a lack of sensation ...
Excessive exposure to oxygen can lead to oxygen toxicity, also known as oxygen toxicity syndrome, oxygen intoxication, and oxygen poisoning.There are two main ways in which oxygen toxicity can occur: exposure to significantly elevated partial pressures of oxygen for a short period of time (acute oxygen toxicity), or exposure to more modest elevations in oxygen partial pressures but for a ...
Histidine residues in hemoglobin can accept protons and act as buffers.Deoxygenated hemoglobin is a better proton acceptor than the oxygenated form. [1]In red blood cells, the enzyme carbonic anhydrase catalyzes the conversion of dissolved carbon dioxide to carbonic acid, which rapidly dissociates to bicarbonate and a free proton:
The arteriovenous oxygen difference is usually taken by comparing the difference in the oxygen concentration of oxygenated blood in the femoral, brachial, or radial artery and the oxygen concentration in the deoxygenated blood from the mixed supply found in the pulmonary artery (as an indicator of the typical mixed venous supply). [citation needed]