Search results
Results from the WOW.Com Content Network
Protein production is the biotechnological process of generating a specific protein. It is typically achieved by the manipulation of gene expression in an organism such that it expresses large amounts of a recombinant gene .
The CENPA protein is a histone H3 variant which replaces one or both canonical H3 histones in a subset of nucleosomes within centromeric chromatin. [ 9 ] [ 10 ] CENPA has the greatest sequence divergence of the histone H3 variants, with just 48% similarity to canonical histone H3, and has a highly diverged N-terminal tail that lacks many well ...
In mice, hypomorphic mutations in condensin II subunits cause specific defects in T cell development, [106] leading to T cell lymphoma. [107] It is interesting to note that cell types with specialized cell division modes, such as neural stem cells and T cells , are particularly susceptible to mutations in condensin subunits.
In humans, the MSTN gene is located on the long (q) arm of chromosome 2 at position 32.2. [5] Myostatin (also known as growth differentiation factor 8, abbreviated GDF8) is a protein that in humans is encoded by the MSTN gene. [6] Myostatin is a myokine that is produced and released by myocytes and acts on muscle cells to inhibit muscle growth. [7]
Fluorescence microscopy micrographs, showing the endogenous human protein Mad1 (one of the spindle checkpoint components) in green, along the different phases in mitosis; CENP-B, in red, is a centromeric marker, and DAPI (in blue) stains DNA. The first protein to be assembled on the kinetochore is CENP-A (Cse4 in Saccharomyces cerevisiae).
The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of ...
The N-terminal maltase-glucoamylase enzymatic unit is in turn composed of 5 specific protein domains. The first of the 5 protein domains consist of a P-type trefoil domain [13] containing a cysteine rich domain. Second is an N-terminal beta-sandwich domain, identified via two antiparallel beta pleated sheets. The third and largest domain ...
However, the Anopheles gambiae sequence has a longer N-terminal extension than the human enzyme and contains the conserved histidine and cysteine heme ligand residues like the human heme. Therefore, it is possible that CBS in slime molds and insects are hemeproteins that suggest that the heme domain is an early evolutionary innovation that ...