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Two genes most commonly associated with some other women's cancers, BRCA1 and BRCA2, do not cause endometrial cancer. There is an apparent link with these genes but it is attributable to the use of tamoxifen, a drug that itself can cause endometrial cancer, in breast and ovarian cancers. [17]
Therefore, endometrial changes, including cancer, are among tamoxifen's side effects. [49] With time, risk of endometrial cancer may be doubled to quadrupled, which is a reason tamoxifen is typically only used for five years. [50] The American Cancer Society lists tamoxifen as a known carcinogen, stating that it increases the risk of some types ...
Few tamoxifen users have had increased rates of uterine cancer, hot flushes, and thromboembolisms. The drug can also cause hepatocarcinomas in rats. This is likely due to the ethyl group of the tamoxifen stilbene core that is subject to allylic oxidative activation causing DNA alkylation and strand scission.
Here’s what oncologists want everyone to know about endometrial cancer, including what it is, what causes it and what treatment looks like. Related: If You Have This Extremely Common Health ...
Endometrial cancer: obesity, metabolic syndrome, type 2 diabetes, tamoxifen use, unopposed estrogens, late menopause, family history of the condition [1] Uterine sarcoma : radiation therapy to the pelvis [ 2 ]
Tamoxifen is currently first-line treatment for nearly all pre-menopausal women with hormone receptor-positive breast cancer. [1] Raloxifene is another partial agonist SERM which does not seem to promote endometrial cancer, and is used primarily for chemoprevention of breast cancer in high-risk individuals, as well as to prevent osteoporosis. [1]
But in the new study, which included data for about 1,500 Black patients, more than 11% of those with endometrial cancer (24 of 210 people) had endometrial thickness measurements that fell within ...
Taking tamoxifen for five years has been found to halve the breast cancer risk in women who have a high risk of breast cancer for any reason, but potentially serious adverse effects like cataracts, blood clots, and endometrial cancer, along with quality of life issues like hot flashes, result in some women discontinuing its use and some ...