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Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease, also known as pseudogout and pyrophosphate arthropathy, is a rheumatologic disease which is thought to be secondary to abnormal accumulation of calcium pyrophosphate dihydrate crystals within joint soft tissues. [1] The knee joint is most commonly affected. [2]
In pseudogout, a form of calcium crystals accumulate in joint cartilage and fluid, causing the same sudden joint pain and swelling as gout. Pseudogout typically affects people over the age of 60 ...
Crystal arthropathy is a class of joint disorder (called arthropathy) that is characterized by accumulation of tiny crystals in one or more joints. Polarizing microscopy and application of other crystallographic techniques have improved identification of different microcrystals including monosodium urate , calcium pyrophosphate dihydrate ...
712 Crystal arthropathies. 712.1 Chondrocalcinosis due to dicalcium phosphate crystals; 712.2 Chondrocalcinosis due to pyrophosphate crystals; 712.3 Chondrocalcinosis, cause unspecified pseudogout; 712.8 Other specified crystal arthropathies; 712.9 Unspecified crystal arthropathy; 713 Arthropathy, endocrine disorders. 713.1 Arthropathy ...
For example, gout in ankles or gout in knee joints may also occur. Gout in hands is less common but can happen. In this situation, it usually affects small joints in the fingers.
Pseudogout (also referred to as calcium pyrophosphate dihydrate crystal deposition disease) is another type of crystalline arthritis that presents very similarly to gout but is caused by the deposition of rhomboid-shaped calcium pyrophosphate dihydrate (CPPD) crystals. The knees, wrists, and fingers are the most common joints affected by ...
Local supersaturation is a common trigger of crystallization, and when the nucleus of the crystalline structure is formed, crystals can self-perpetuate and cause more crystallization and aggregation. Main mechanisms by which the formed crystals and aggregates cause pathological states and ultimately disease are acute necroinflammation , chronic ...
Gout is caused by deposition of uric acid crystals in the joints, causing inflammation. There is also an uncommon form of gouty arthritis caused by the formation of rhomboid crystals of calcium pyrophosphate known as pseudogout. In the early stages, the gouty arthritis usually occurs in one joint, but with time, it can occur in many joints and ...
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