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Standardized Kt/V, also std Kt/V, is a way of measuring dialysis adequacy. It was developed by Frank Gotch and is used in the United States to measure dialysis. Despite the name, it is quite different from Kt/V. In theory, both peritoneal dialysis and hemodialysis can be quantified with std Kt/V.
where C is the concentration [mol/m 3]; t is the time [s]; K is the clearance [m 3 /s]; V is the volume of distribution [m 3]; From the above definitions it follows that is the first derivative of concentration with respect to time, i.e. the change in concentration with time.
A more accurate relationship between URR and Kt/V can be derived by single-pool, variable volume urea kinetic modeling. A simplified estimating equation also can be used. [ 2 ] This gives results that are quite similar to formal urea modeling as long as dialysis treatments of 2–6 hours in duration are given, and Kt/V is between 0.7 and 2.0.
Nomogram: Standard(ized)Kt/V vs. Treatment Kt/V by Number of Treatments per Week: 00:34, 11 February 2007: 574 × 499 (68 KB) Jtdaugir (talk | contribs)
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Frank A. Gotch (August 27, 1926 – February 18, 2017) was an American physician known for his work in renal dialysis adequacy, specifically the development of Kt/V and standardized Kt/V. He was an associate professor of medicine at the University of California, San Francisco .
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