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Low energy levels and stress: The AMP-dependent protein kinase AMPK phosphorylates and thereby activates TSC1-TSC2 by phosphorylating at least 2 residues of TSC2. [7] Hypoxia: The Hypoxia-inducible factor α HIFα induces REDD1 at low oxygen levels. REDD1 has been shown to activate TSC1-TSC2 by neutralisation of AKT dependent inhibition. [8]
Pharmacological inhibition of ERK1/2 restores GSK3β activity and protein synthesis levels in a model of tuberous sclerosis. [8]The defective degradation of glycogen by the autophagy-lysosome pathway is, at least in part, independent of impaired regulation of mTORC1 and is restored by the combined use of PKB/Akt and mTORC1 pharmacological inhibitors.
Tuberous sclerosis complex (TSC) is a rare multisystem autosomal dominant genetic disease that causes non-cancerous tumours to grow in the brain and on other vital organs such as the kidneys, heart, liver, eyes, lungs and skin.
TSC1 functions as a co-chaperone which inhibits the ATPase activity of the chaperone Hsp90 (heat shock protein-90) and decelerates its chaperone cycle. TSC1 functions as a facilitator of Hsp90 in chaperoning the kinase and non-kinase clients including TSC2, therefore preventing their ubiquitination and degradation in the proteasome. [6]
Simone Segouin (French: [simɔn səɡwɛ̃]; 3 October 1925 – 21 February 2023), also known by her nom de guerre Nicole Minet (French: [nikɔl minɛ]), was a French Resistance fighter who served in the Francs-tireurs et partisans group during World War II. Among her first acts of resistance was stealing a bicycle from a German patrol, which ...
In 1946, the Department of Defense Dependent Schools was created for dependents of military members of the armed forces in overseas areas. [1] After World War II, the increased demand for American education overseas was a result of the government's decision to allow soldiers to bring their families when deployed.
A dependant (US spelling: dependent) is a person who relies on another as a primary source of income. A common-law spouse who is financially supported by their partner may also be included in this definition. [1] In some jurisdictions, supporting a dependant may enable the provider to claim a tax deduction.
A theater sustainment command is a United States Army logistics headquarters. The theater sustainment command is the senior army logistics command in a theater. The command is a modular organization tailored to meet specific requirements of the theater.