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Low energy levels and stress: The AMP-dependent protein kinase AMPK phosphorylates and thereby activates TSC1-TSC2 by phosphorylating at least 2 residues of TSC2. [7] Hypoxia: The Hypoxia-inducible factor α HIFα induces REDD1 at low oxygen levels. REDD1 has been shown to activate TSC1-TSC2 by neutralisation of AKT dependent inhibition. [8]
Pharmacological inhibition of ERK1/2 restores GSK3β activity and protein synthesis levels in a model of tuberous sclerosis. [8]The defective degradation of glycogen by the autophagy-lysosome pathway is, at least in part, independent of impaired regulation of mTORC1 and is restored by the combined use of PKB/Akt and mTORC1 pharmacological inhibitors.
Tuberous sclerosis complex (TSC) is a rare multisystem autosomal dominant genetic disease that causes non-cancerous tumours to grow in the brain and on other vital organs such as the kidneys, heart, liver, eyes, lungs and skin.
TSC1 functions as a co-chaperone which inhibits the ATPase activity of the chaperone Hsp90 (heat shock protein-90) and decelerates its chaperone cycle. TSC1 functions as a facilitator of Hsp90 in chaperoning the kinase and non-kinase clients including TSC2, therefore preventing their ubiquitination and degradation in the proteasome. [6]
Simone Segouin (French: [simɔn səɡwɛ̃]; 3 October 1925 – 21 February 2023), also known by her nom de guerre Nicole Minet (French: [nikɔl minɛ]), was a French Resistance fighter who served in the Francs-tireurs et partisans group during World War II. Among her first acts of resistance was stealing a bicycle from a German patrol, which ...
Xenix 386, Unix System V Release 2 based distribution for the Intel 80386 architecture; SCO Unix, SCO UNIX System V/386 was the first volume commercial product licensed by AT&T to use the UNIX System trademark (1989). Derived from AT&T System V Release 3.2 with an infusion of Xenix device drivers and utilities plus most of the SVR4 features
As her father was a serving army officer, the first 10 years of Walters's life were spent moving between army bases in the north and south of England. Her father died from kidney failure in 1960. While raising Walters and her two brothers, Colleen Jebb painted miniatures from photographs to supplement the family's income. [2]
Bernard Minet (born 28 December 1953 in Hénin-Beaumont as Bernard Wantier) is a French singer and actor. He started his career in Pas-de-Calais in 1969 and arrived in Paris in 1970, where he was part of several bands during his studies: "Pop", the "Baloches" and the "Golf Drouot."