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This, the scientists say, is well under the current threshold for good value interventions of about £20,000 (about $26,000) per quality-adjusted life years gained.
After six weeks, The National Cholesterol Education Program recommends checking the LDL cholesterol response to the changes; if the LDL cholesterol goal has not been achieved, other therapeutic options for LDL lowering can be implemented. These include: 2 grams per day of plant stanols or sterols and 10–25 grams per day of soluble fiber.
25 to <50 <1.3 Optimal LDL cholesterol, levels in healthy young children before onset of atherosclerotic plaque in heart artery walls <70 <1.8 Optimal LDL cholesterol, corresponding to lower rates of progression, promoted as a target option for those known to clearly have advanced symptomatic cardiovascular disease <100 <2.6
Guidelines by the American College of Cardiology and the American Heart Association recommend statin treatment for primary prevention of cardiovascular disease in adults with LDL cholesterol ≥ 190 mg/dL (4.9 mmol/L) or those with diabetes, age 40–75 with LDL-C 70–190 mg/dL (1.8–4.9 mmol/dL); or in those with a 10-year risk of developing ...
The goal of maintaining optimal lipid levels throughout life is to keep the concentration of circulating LDL and other apo B–containing lipoproteins low to minimize the number of particles that become retained in the arterial wall and thereby minimize the rate of progression of atherosclerotic plaques.
4018 n/a Ensembl ENSG00000198670 n/a UniProt P08519 n/a RefSeq (mRNA) NM_005577 n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 6: 160.53 – 160.66 Mb n/a PubMed search n/a Wikidata View/Edit Human Lipoprotein(a) is a low-density lipoprotein variant containing a protein called apolipoprotein(a). Genetic and epidemiological studies have identified lipoprotein(a) as a risk factor for ...
In Canada, screening is recommended for men 40 and older and women 50 and older. [48] In those with normal cholesterol levels, screening is recommended once every five years. [49] Once people are on a statin further testing provides little benefit except possibly to determine compliance with treatment. [50]
Remnant cholesterol has about twice the association with ischemic heart disease as LDL cholesterol. [14] Although remnant cholesterol tends to be higher in people who are overweight (high body mass index), normal-weight persons with high remnant cholesterol tend to have a higher risk of myocardial infarction. [15]