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  2. Epitopoietic Research Corporation - Wikipedia

    en.wikipedia.org/wiki/Epitopoietic_Research...

    Stathopoulos conducts a proof-of-concept study on rats. The study finds that the combination of Syngeneic and allogeneic glioma cells injected into rats with growing tumors reduces the size, eradicates the existing tumors, and prevents the formation of new tumors. Stathopoulos patents the technique and founds ERC to develop the treatment for ...

  3. Lewis lung carcinoma - Wikipedia

    en.wikipedia.org/wiki/Lewis_lung_carcinoma

    According to a 2015 review article, Lewis lung carcinoma is the only reproducable syngeneic lung cancer model, meaning that it is the only reproducible lung cancer model that utilizes a transplant that is immunologically compatible. Syngeneic models have proven to be useful in predicting clinical benefit of therapy in preclinical experiments.

  4. Immunoediting - Wikipedia

    en.wikipedia.org/wiki/Immunoediting

    Cells of the innate immune system recognize the presence of a growing tumor which has undergone stromal remodeling, causing local tissue damage. This is followed by the induction of inflammatory signals which is essential for recruiting cells of the innate immune system (e.g. natural killer cells , natural killer T cells, macrophages and ...

  5. Cancer immunology - Wikipedia

    en.wikipedia.org/wiki/Cancer_immunology

    Tumor-associated immune cells in the tumor microenvironment (TME) of breast cancer models. Cancer immunology (immuno-oncology) is an interdisciplinary branch of biology and a sub-discipline of immunology that is concerned with understanding the role of the immune system in the progression and development of cancer; the most well known application is cancer immunotherapy, which utilises the ...

  6. Lymphokine-activated killer cell - Wikipedia

    en.wikipedia.org/wiki/Lymphokine-activated...

    A study has shown that ICAM1 in lung cancer cells increases LAK cell-mediated tumor cell death as a new anti-tumor mechanism. [6] One study uses a 4 hour chromium release assay, which is an assay used to measure the cytotoxicity of T cells and natural killer cells, to measure lysis of the fresh solid tumor cells from 10 cancer patients and ...

  7. Axelopran - Wikipedia

    en.wikipedia.org/wiki/Axelopran

    The study of axelopran in MC-38 syngeneic colorectal cancer in mice in combination with murine anti-PD-1 antibody tested the effect of a μ-opioid blockade on tumor volume and survival in a full in vivo model with both fully functional immune system and mature gut function and enteric microbiome.

  8. Xenotransplantation - Wikipedia

    en.wikipedia.org/wiki/Xenotransplantation

    Xenotransplantation of human tumor cells into immunocompromised mice is a research technique frequently used in oncology research. [45] It is used to predict the sensitivity of the transplanted tumor to various cancer treatments; several companies offer this service, including the Jackson Laboratory. [46]

  9. Syngenic - Wikipedia

    en.wikipedia.org/wiki/Syngenic

    Syngeneic refers to a graft transferred between genetically identical animals or people. [1] A syngeneic graft is known as an isograft. [2] Related terms include: [citation needed] autogeneic, referring to autotransplantation, also termed autograft, (from one part of the body to another in the same person)