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Doudna's awards and fellowships include the 2000 Alan T. Waterman Award for her research on the structure of a ribozyme, as determined by X-ray crystallography [9] and the 2015 Breakthrough Prize in Life Sciences for CRISPR-Cas9 genome editing technology, with Charpentier. [10]
Charpentier is best known for her Nobel-winning work of deciphering the molecular mechanisms of a bacterial immune system, called CRISPR/Cas9, and repurposing it into a tool for genome editing. In particular, she uncovered a novel mechanism for the maturation of a non-coding RNA which is pivotal in the function of CRISPR/Cas9.
The CRISPR-Cas9 genome editing technique was a significant contributor to the Nobel Prize in Chemistry in 2020 being awarded to Emmanuelle Charpentier and Jennifer Doudna. [ 2 ] More technically, Cas9 is a RNA -guided DNA endonuclease enzyme associated with the Clustered Regularly Interspaced Short Palindromic Repeats ( CRISPR ) adaptive immune ...
Cas9 (or "CRISPR-associated protein 9") is an enzyme that uses CRISPR sequences as a guide to recognize and open up specific strands of DNA that are complementary to the CRISPR sequence. Cas9 enzymes together with CRISPR sequences form the basis of a technology known as CRISPR-Cas9 that can be used to edit genes within living organisms.
In his new book “The Catalyst,” Thomas R. Cech talks about the Covid-19 vaccines, what RNA means for future health crises and how gene editing with CRISPR factors in.
This is the first time two women scientists have jointly won a Nobel Prize in Chemistry. [23] In June 2021, Intellia made history by announcing interim Phase 1 data for NTLA-2001, demonstrating the ability to precisely edit target cells within the body to treat genetic disease with a single intravenous infusion of CRISPR.
CRISPR Therapeutics was founded in 2013 by Emmanuelle Charpentier, Shaun Foy and Rodger Novak. [6] Charpentier later shared the Nobel Prize in Chemistry in 2020 with Jennifer Doudna. As part of a working group, she provided the first scientific documentation on the development and use of CRISPR gene editing. This allows DNA to be specifically ...
On October 7, 2020, the Nobel Prize in Chemistry was awarded to Doudna and Charpentier for their work on developing CRISPR-Cas9 gene editing. [ 31 ] [ 32 ] Doudna was unable to attend the traditional live awards ceremony in Stockholm due to the COVID-19 pandemic, so she accepted the award at her home in Berkeley, California, and celebrations ...