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In calculus, integration by substitution, also known as u-substitution, reverse chain rule or change of variables, [1] is a method for evaluating integrals and antiderivatives. It is the counterpart to the chain rule for differentiation , and can loosely be thought of as using the chain rule "backwards."
In this type of substitution reaction, one group of the substrate participates initially in the reaction and thereby affects the reaction. A classic example of NGP is the reaction of a sulfur or nitrogen mustard with a nucleophile, the rate of reaction is much higher for the sulfur mustard and a nucleophile than it would be for a primary or secondary alkyl chloride without a heteroatom.
Integration, the process of computing an integral, is one of the two fundamental operations of calculus, [a] the other being differentiation. Integration was initially used to solve problems in mathematics and physics, such as finding the area under a curve, or determining displacement from velocity. Usage of integration expanded to a wide ...
Using Euler's formula, any trigonometric function may be written in terms of complex exponential functions, namely and and then integrated. This technique is often simpler and faster than using trigonometric identities or integration by parts , and is sufficiently powerful to integrate any rational expression involving trigonometric functions.
The substitutions of Euler can be generalized by allowing the use of imaginary numbers. For example, in the integral +, the substitution + = + can be used. Extensions to the complex numbers allows us to use every type of Euler substitution regardless of the coefficients on the quadratic.
Change of variables is an operation that is related to substitution. However these are different operations, as can be seen when considering differentiation or integration (integration by substitution). A very simple example of a useful variable change can be seen in the problem of finding the roots of the sixth-degree polynomial:
or equivalently, = ()because of the substitution rule for integrals.. If one can evaluate the two integrals, one can find a solution to the differential equation. Observe that this process effectively allows us to treat the derivative as a fraction which can be separated.
Organic azides also provide an example of an insertion reaction in organic synthesis and, like the above examples, the transformations proceed with loss of nitrogen gas. When tosyl azide reacts with norbornadiene, a ring expansion reaction takes place in which a nitrogen atom is inserted into a carbon-carbon bond α- to the bridge head: [14]