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Autologous stem-cell transplantation is distinguished from allogenic stem cell transplantation where the donor and the recipient of the stem cells are different people. [2] It can be also used as an Assisted reproductive technology to improve the reproductive outcomes. In a first step the bone marrow derived stem cells are mobilized.
Allogeneic transplant donors may be related (usually a closely HLA-matched sibling), syngeneic (a monozygotic or identical twin of the patient – necessarily extremely rare since few patients have an identical twin, but offering a source of perfectly HLA-matched stem cells), unrelated (donor who is not related and found to have very close ...
Allotransplant (allo-meaning "other" in Greek) is the transplantation of cells, tissues, or organs to a recipient from a genetically non-identical donor of the same species. [1] The transplant is called an allograft, allogeneic transplant, or homograft. Most human tissue and organ transplants are allografts.
The transplantation may be autologous (an individual's own blood cells), allogeneic (blood cells donated by someone else with matching HLA), or syngeneic (blood cells donated by an identical twin). The apheresis procedure typically lasts for 4–6 hours, depending on the blood volume of the donor.
Autotransplantation is the transplantation of organs, tissues, or even particular proteins from one part of the body to another in the same person (auto-meaning "self" in Greek [1]). The autologous tissue (also called autogenous, autogeneic, or autogenic tissue) transplanted by such a procedure is called an autograft or autotransplant. [2]
When the cells are collected from the same patient on whom they will be used, a graft is called autologous. Syngeneic refers to a graft transferred between genetically identical animals or people. [1] A syngeneic graft is known as an isograft. [2] Related terms include: [citation needed]
Hematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood. [16] [17] [13] It may be autologous (the patient's own stem cells are used), allogeneic (the stem cells come from a donor) or syngeneic (from an identical twin).
Stem-cell therapy uses stem cells to treat or prevent a disease or condition. [1] As of 2024, the only FDA-approved therapy using stem cells is hematopoietic stem cell transplantation. [2] [3] This usually takes the form of a bone marrow or peripheral blood stem cell transplantation, but the cells can also be derived from umbilical cord blood.
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