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The Nikolsky sign is dislodgement of intact superficial epidermis by a shearing force, indicating a plane of cleavage in the skin epidermal-epidermal junctions (e.g., desmosomes). The histological picture involves thinner, weaker attachments of the skin lesion itself to the normal skin – resulting in easier dislodgement.
SSSS is a clinical diagnosis. This is sometimes confirmed by isolation of S. aureus from blood, mucous membranes, or skin biopsy; however, these are often negative. Skin biopsy may show separation of the superficial layer of the epidermis (intraepidermal separation), differentiating SSSS from TEN, wherein the separation occurs at the dermo-epidermal junction (subepidermal separation).
The sloughing of skin associated with certain varieties of this condition is now referred to as Nikolsky's sign. In 1898, he became a professor at the Imperial University of Warsaw, and later established the Department of Dermatology and Venerology in Rostov at what is now Rostov State Medical University. [1]
The Asboe-Hansen sign (also known as "indirect Nikolsky sign'" [1] or "Nikolsky II sign" [1]) refers to the extension of a large blister to adjacent unblistered skin when pressure is put on the top of it.
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Nikolsky's sign (gentle lateral pressure) on unaffected mucosa or skin raises a bulla. If no lesions are present on examination it may be useful way of demonstrating reduced epithelial adhesion. If no lesions are present on examination it may be useful way of demonstrating reduced epithelial adhesion.
Example of an activity book. An activity book is a type of book, generally aimed at children, which contains interactive content such as games, puzzles, quizzes, pictures to colour and other elements that involve writing or drawing in the book itself.
Printable version; In other projects Wikidata item; Appearance. move to sidebar hide. Nikolsky (Russian: Никольский) is a surname. Notable people with the ...
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