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A steroidal antiandrogen (SAA) is an antiandrogen with a steroidal chemical structure. [1] [2] [3] They are typically antagonists of the androgen receptor (AR) and act both by blocking the effects of androgens like testosterone and dihydrotestosterone (DHT) and by suppressing gonadal androgen production.
A study found that oral spironolactone had "about 10 to 20% of the feminizing effect of cyproterone acetate" on sexual differentiation in male rat fetuses, with a dose of 40 mg/day spironolactone having an effect equal to 1–3 mg/day cyproterone acetate. [35] [36]
Testosterone, the major endogenous androgen and the target mediator of antiandrogens.. This is a list of antiandrogens, [1] or drugs that prevent the effects of androgens like testosterone and dihydrotestosterone (DHT). [2]
Cyproterone acetate (CPA), sold alone under the brand name Androcur or with ethinylestradiol under the brand names Diane or Diane-35 among others, is an antiandrogen and progestin medication used in the treatment of androgen-dependent conditions such as acne, excessive body hair growth, early puberty, and prostate cancer, as a component of feminizing hormone therapy for transgender individuals ...
Testosterone levels with 100 to 300 mg/day oral cyproterone acetate and low-dose oral estrogen in men. [160] The estrogen used was 0.1 mg/day diethylstilbestrol (DES), [160] which has been described as an "extremely low" dosage. [87] Levels of testosterone were decreased by about 95% with the combination and by about 61% with cyproterone ...
1967: Cyproterone acetate was first studied clinically, to treat sexual deviance in men [225] 1969: Cyproterone acetate was first studied in the treatment of acne, hirsutism, seborrhea, and scalp hair loss in women [226] 1969: The antiandrogenic activity of spironolactone is discovered [227]
Co-cyprindiol, a shortened form of combination of cyproterone acetate and ethinylestradiol, is a generic name of EE/CPA. [ 25 ] [ 26 ] [ 27 ] It is also known by its former developmental code names SHB 209 AB (Diane) [ 28 ] [ 21 ] [ 29 ] and SHB 209 AE (Diane-35).
They are common during spironolactone therapy, with 10 to 50% of women experiencing them at moderate doses and almost all experiencing them at a high doses. [86] [111] For example, about 20% of women experienced menstrual irregularities with 50 to 100 mg/day spironolactone, whereas about 70% experienced menstrual irregularities at 200 mg/day. [63]
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